Extrapolating results of toxicological studies in experimental animals to derive quantitive risk standards for human exposure tolerance - ACJ & Associates contributed to Chapter 10 entitled "Dosimetry of inhaled Particles in the Respiratory Tract", a part of the USEPA's scientific evaluation of Air Quality Criteria for Particulate Matter and the scientific basis for review, and revision, of the U.S National Ambient Air Quality Standards (NAAQA). Our Contribution consisted of the application of the ICRP Human Respiratory Tract Model for Radiological Protection to predict the deposition and retention of inhaled, non-radioactive, ambient atmospheric particulate matter in the human lungs for various different demographic groups.
This work, in collaboration with Annie M. Jarabek (USEPA National Center for Environmental Assessment, Research Triangle Park, NC), and Burt Snipes (Lovelace Respiratory Research Institute, Albuquerque, NM), was presented by Burt Snipes at the 1997 Annual Meeting of the Society of Toxicology, Cincinnati, OH - and we received the "Outstanding Presentation' award.
Improved Models of Particle Deposition and Retention in the Lungs of Laboratory Animals - The USEPA's review of the scientific basis for extrapolating results of toxicological studies in experimental animals to predict cumulative lung burdens in humans exposed to environmental pollutants revealed substantial short-comings in the currently appled methods to model and synthesize the basic experimental data in different animal species. A.C.J & Associates, Inc. has been awarded research contacts by the National Center for Environmental Assessment to apply the methodologies developed by the ICRP Task Group responsible for ICRP Publication 66 (1994) to develop better empirical models of regional deposition and particulate retention in the respiratory tract of the rat, mouse, hamster, guinea pig, and rabbit, taking into account the animals' breathing behavior, body weight, age, and gender. Dr. James led the ICRP Task Group's work on developing the aerosol deposition and tissue dosimetry models that are adopted in the "Human Respiratory Tract Model for Radiological Protection".
